Interleukin-5 regulates genes involved in B-cell terminal maturation
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چکیده
منابع مشابه
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Grb2 is a ubiquitously expressed adaptor protein, which activates Ras and MAP kinases in growth factor receptor signalling, while in B-cell receptor (BCR) signalling this role is controversial. In B cell lines it was shown that Grb2 can inhibit BCR-induced Ca(2+) signalling. Nonetheless, the physiological role of Grb2 in primary B cells is still unknown. We generated a B-cell-specific Grb2-defi...
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OBJECTIVE Natural immunity is emerging as an important mediator of protection from atherogenesis. Natural IgM antibodies that recognize oxidation-specific epitopes on low-density lipoprotein or phospholipids and the B-1a B cells that produce them attenuate atherosclerosis. We previously demonstrated that Apoe(-/-) mice globally deficient in the helix-loop-helix protein inhibitor of differentiat...
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ژورنال
عنوان ژورنال: Immunology
سال: 2006
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2006.02382.x